[Pubertal delay].

Puberty is the phenomenon that conducts to reproductive maturation. Delayed puberty is defined in girls by the absence of breast development beyond 13-years-old or primary amenorrhea beyond 15-years-old, and in boys by the absence of testicular development beyond 14-years-old. Most delayed puberties are functional. Congenital hypogonadotrophic hypogonadism are rare. Turner syndrome is the most frequent hypergonadotrophic hypogonadism in girls. The delayed puberty treatment is hormonal replacement. Delayed puberty clearly has a genetic component, and new advances in genetic research may provide tools to aid our understanding of the factors that regulate the timing of puberty.