来自家猫（Felis catus）和非洲狮（Panthera leo）的基因不同的猫免疫缺陷病毒株共用CD134和CXCR4作为进入受体。
Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors.
作者信息
McEwan William A, McMonagle Elizabeth L, Logan Nicola, Serra Rodrigo C, Kat Pieter, Vandewoude Sue, Hosie Margaret J, Willett Brian J
机构信息
Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom.
出版信息
J Virol. 2008 Nov;82(21):10953-8. doi: 10.1128/JVI.01312-08. Epub 2008 Aug 20.
The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.
来自非洲不同地理区域的非洲狮（Panthera leo）慢病毒（猫免疫缺陷病毒 [FIV(Ple)]）B 亚型和 E 亚型的 env 开放阅读框表明有两个不同的祖先，其中 FIV(Ple)-E 与家猫（Felis catus）慢病毒（FIV(Fca)）有一个共同的祖先。在这里，我们证明 FIV(Ple)-E 和 FIV(Fca) 分别共用 CD134（OX40）和 CXCR4 作为主要受体和共受体，并且狮子的 CD134 和 CXCR4 都是 FIV(Ple)-E 的功能性受体。FIV(Fca) 和 FIV(Ple)-E 对 CD134 和 CXCR4 的共用可能对自由放养狮子种群中 E 亚型的体内细胞嗜性和致病性有影响。
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