Yamada Jiko, Tomiyama Hirofumi, Matsumoto Chisa, Yoshida Masanobu, Koji Yutaka, Shiina Kazuki, Nagata Mikio, Yamashina Akira
Second Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Hypertens Res. 2008 Jun;31(6):1087-92. doi: 10.1291/hypres.31.1087.
The present study was conducted to clarify whether body mass index (BMI [kg/m(2)]) classifications (i.e., without excess weight, overweight, and obese) modify the rate of progression of arterial stiffening, a cardiovascular risk factor associated with weight gain. A 3-year observational study was conducted in 2,080 healthy middle-aged Japanese men (aged 42+/-10 years). Brachial-ankle pulse wave velocity (baPWV) was measured at the beginning and end of the study period. In overweight subjects (30>BMI>or=25), the estimated annual rate of increase of baPWV (ARbaPWV) in subjects with weight gain (>or=5% weight gain; ARbaPWV, 21.8+/-4.4 cm/s/year) was significantly higher than in those without weight gain (<5% weight gain; ARbaPWV, 12.5+/-1.6 cm/s/year), after adjustments for changes in blood pressure and other variables (p<0.05). This change was not observed in subjects without excess weight (BMI<25) or in obese subjects (BMI>or=30). The increase in the ARbaPWV associated with weight gain in the overweight group was also higher than that in the without excess body weight or obese groups. Our study revealed that the BMI classifications modified the annual rate of increase in arterial stiffening associated with weight gain. Weight gain seemed to accelerate arterial stiffening in overweight subjects, but not in subjects without excess weight. The weight gain in overweight subjects seemed to worsen the cardiovascular risk related to arterial stiffness in middle-aged healthy Japanese men. Thus, the prevention of weight gain should be emphasized in overweight subjects.
本研究旨在阐明体重指数（BMI[kg/m²]）分类（即无超重、超重和肥胖）是否会改变动脉僵硬度的进展速度，动脉僵硬度是一种与体重增加相关的心血管危险因素。对2080名健康的中年日本男性（年龄42±10岁）进行了一项为期3年的观察性研究。在研究期开始和结束时测量肱踝脉搏波速度（baPWV）。在超重受试者（30>BMI≥25）中，体重增加的受试者（体重增加≥5%；baPWV年增长率[ARbaPWV]，21.8±4.4cm/s/年）的baPWV估计年增长率显著高于体重未增加的受试者（体重增加<5%；ARbaPWV，12.5±1.6cm/s/年），在对血压变化和其他变量进行调整后（p<0.05）。在无超重（BMI<25）的受试者或肥胖受试者（BMI≥30）中未观察到这种变化。超重组中与体重增加相关的ARbaPWV增加也高于无超重或肥胖组。我们的研究表明，BMI分类改变了与体重增加相关的动脉僵硬度年增长率。体重增加似乎会加速超重受试者的动脉僵硬度，但不会加速无超重受试者的动脉僵硬度。超重受试者的体重增加似乎会加重中年健康日本男性与动脉僵硬度相关的心血管风险。因此，应强调超重受试者预防体重增加。
