Sung Ki-Chul
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Pulse (Basel). 2023 Dec 21;12(1):12-18. doi: 10.1159/000535775. eCollection 2024 Jan-Dec.
Diabetes may induce multiple organ damage; therefore, early detection of individuals at high-risk of incident diabetes is important for timely risk assessment and intervention. Arterial stiffness (AS) occurs as a result of functional and structural changes in the arterial wall. Growing body of evidence suggests that AS is a risk factor for incident diabetes. Although each study could use different indicators for AS (ex cf-PWV, baPWV, etc.), they came to similar conclusion that AS was associated with higher risk of incident diabetes. The underlying mechanisms for the relationship of AS with risk of diabetes remain to be elucidated, but there could be several potential mechanisms. Diabetes and AS are expected to share common risk factors and influence each other, but recent research showed some evidence that AS can directly increase the risk of diabetes. The link between AS and incident diabetes has important clinical implications. First, it suggests that AS might be a useful marker for identifying people at high risk for developing diabetes. Second, it suggests that reducing AS may prevent or delay the onset of diabetes. Early detection and possible slowing of the vascular stiffening process with pharmacological agents and lifestyle interventions may reduce associated risks for diabetes.
糖尿病可能会导致多器官损害；因此，早期发现糖尿病发病高危个体对于及时进行风险评估和干预至关重要。动脉僵硬（AS）是动脉壁功能和结构改变的结果。越来越多的证据表明，AS是糖尿病发病的一个危险因素。尽管每项研究可能使用不同的AS指标（如cf-PWV、baPWV等），但他们得出了相似的结论，即AS与糖尿病发病风险较高相关。AS与糖尿病风险之间关系的潜在机制仍有待阐明，但可能存在几种潜在机制。糖尿病和AS预计有共同的危险因素且相互影响，但最近的研究显示有一些证据表明AS可直接增加糖尿病风险。AS与糖尿病发病之间的联系具有重要的临床意义。首先，这表明AS可能是识别糖尿病发病高危人群的有用标志物。其次，这表明降低AS可能预防或延缓糖尿病的发生。通过药物治疗和生活方式干预早期发现并可能减缓血管硬化过程，可能会降低糖尿病的相关风险。
