Kashikar-Zuck Susmita, Parkins Irina S, Graham Thomas Brent, Lynch Anne M, Passo Murray, Johnston Megan, Schikler Kenneth N, Hashkes Philip J, Banez Gerard, Richards Margaret M
Division of Behavioral Medicine and Clinical Psychology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Clin J Pain. 2008 Sep;24(7):620-6. doi: 10.1097/AJP.0b013e31816d7d23.
Mood and anxiety disorders are common psychiatric conditions among adult patients with fibromyalgia syndrome, but little is known about whether psychiatric disorders are prevalent among pediatric patients with fibromyalgia.
The primary objective of this study was to assess the prevalence of mood, anxiety, and behavioral disorders in a clinical sample of children and adolescents with juvenile primary fibromyalgia syndrome (JPFS) and assess the relationship between psychiatric disorders and JPFS symptom severity.
Standardized psychiatric interviews were conducted with children and their parents/primary caregivers, and measures of symptom severity including pain intensity and physician global ratings were obtained for 76 children and adolescents diagnosed with JPFS (ages 11 to 18 y) in pediatric rheumatology clinics at 4 hospitals in the Midwest.
A total of 67.1% of patients had at least 1 current and 71.5% had at least 1 lifetime DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-fourth edition) psychiatric diagnosis. The most frequent psychiatric diagnosis was anxiety disorder (57.5% of JPFS patients). Although mood difficulties were also common, the presence of major depression was lower than has been reported for adults with fibromyalgia syndrome. Physicians' global assessment of functioning was significantly lower for patients with a current anxiety disorder. There were no significant differences in pain severity among patients with and without anxiety, mood, or behavioral disorders.
There seems to be a high prevalence of anxiety disorders in patients with JPFS, and presence of anxiety disorder is associated with poorer physician-rated functioning. Future research should explore whether early anxiety symptoms are predictive of long-term functioning.
情绪和焦虑障碍在成年纤维肌痛综合征患者中是常见的精神疾病,但对于精神疾病在儿童纤维肌痛患者中是否普遍存在却知之甚少。
本研究的主要目的是评估青少年原发性纤维肌痛综合征(JPFS)患儿及青少年临床样本中情绪、焦虑和行为障碍的患病率,并评估精神疾病与JPFS症状严重程度之间的关系。
对儿童及其父母/主要照顾者进行标准化精神科访谈,并在中西部4家医院的儿科风湿病诊所,对76名诊断为JPFS(年龄11至18岁)的儿童及青少年获取症状严重程度的测量指标,包括疼痛强度和医生整体评分。
共有67.1%的患者目前至少患有一种精神疾病,71.5%的患者一生中至少有一次符合《精神疾病诊断与统计手册》第四版(DSM-IV)的精神疾病诊断。最常见的精神疾病诊断是焦虑障碍(57.5%的JPFS患者)。虽然情绪问题也很常见,但重度抑郁症的发生率低于成年纤维肌痛综合征患者的报告水平。目前患有焦虑障碍的患者,医生对其功能的整体评估显著更低。有无焦虑、情绪或行为障碍的患者在疼痛严重程度上无显著差异。
JPFS患者中焦虑障碍的患病率似乎很高,且焦虑障碍的存在与医生评定的功能较差有关。未来的研究应探索早期焦虑症状是否可预测长期功能。