Yang L, Fujimoto J, Qiu D, Sakamoto N
Department of Maternal and Child Health, National Research Institute for Health and Development, Setagaya-ku, Tokyo, Japan.
Ann Oncol. 2009 Jan;20(1):166-74. doi: 10.1093/annonc/mdn562. Epub 2008 Aug 20.
This paper describes the mortality rates and trends from childhood cancer at the population level over a 37-year period in Japan and other developed countries.
Age-standardized mortality rates were calculated by the direct method using age-specific mortality rates at 5-year age intervals and weights based on the age distribution of the standard world population. The joinpoint regression model was used to describe changes in trends.
For all cancers combined, the mortality rate during 2000-2006 was 2.20 per 100,000 population for boys and 1.89 for girls. Mortality for all cancers combined decreased since 1970s in Japan. A stable trend was observed in recent 5 years for girls. For leukemia, a declining trend was observed in the whole period for girls and in 1976-2006 for boys. Mortality rates for childhood central nervous system tumors have remained stable at a low level during 1980-2006.
The present study provides updated figures and trends in childhood cancer mortality in Japan and other developed countries. This will help to estimate care needs and to plan intervention and the quantity of appropriate childhood cancer treatment.
本文描述了日本及其他发达国家37年间儿童癌症在人群层面的死亡率及趋势。
采用直接法，利用5岁年龄组的年龄别死亡率及基于标准世界人口年龄分布的权重计算年龄标准化死亡率。采用连接点回归模型描述趋势变化。
2000 - 2006年期间，所有癌症合并的死亡率，男孩为每10万人口2.20例，女孩为1.89例。自20世纪70年代以来，日本所有癌症合并的死亡率呈下降趋势。最近5年女孩的死亡率呈稳定趋势。对于白血病，女孩在整个时期以及男孩在1976 - 2006年呈下降趋势。1980 - 2006年期间，儿童中枢神经系统肿瘤的死亡率一直稳定在较低水平。
本研究提供了日本及其他发达国家儿童癌症死亡率的最新数据和趋势。这将有助于估计护理需求，并规划干预措施以及适当的儿童癌症治疗数量。
