• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models.

作者信息

Striessnig Jörg, Koschak Alexandra

机构信息

Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.

出版信息

Channels (Austin). 2008 Jul-Aug;2(4):233-51. doi: 10.4161/chan.2.4.5847. Epub 2008 Jul 11.

DOI:10.4161/chan.2.4.5847
PMID:18719397
Abstract
摘要

相似文献

1
Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models.利用基因敲除模型探索电压门控Ca2+通道的功能及药物治疗潜力。
Channels (Austin). 2008 Jul-Aug;2(4):233-51. doi: 10.4161/chan.2.4.5847. Epub 2008 Jul 11.
2
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.Entla，一种新型的小鼠癫痫和共济失调性Cacna2d2突变体。
J Biol Chem. 2004 Feb 20;279(8):7322-30. doi: 10.1074/jbc.M308778200. Epub 2003 Dec 2.
3
Using mutant mice to study the role of voltage-gated calcium channels in the retina.利用突变小鼠研究视网膜中电压门控钙通道的作用。
Adv Exp Med Biol. 2002;514:439-50. doi: 10.1007/978-1-4615-0121-3_26.
4
Recent advances in the modulation of voltage-gated ion channels for the treatment of epilepsy.用于治疗癫痫的电压门控离子通道调节方面的最新进展。
Curr Drug Targets CNS Neurol Disord. 2002 Feb;1(1):81-104. doi: 10.2174/1568007023339463.
5
Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy.铁诱导癫痫中脱氢表雄酮治疗对电压门控钠和钙通道亚型的反应。
Cell Mol Neurobiol. 2021 Mar;41(2):279-292. doi: 10.1007/s10571-020-00851-0. Epub 2020 Apr 21.
6
[Cerebellar ataxia and absence epilepsy: genes, channels, neurons and mice].[小脑共济失调与失神癫痫：基因、通道、神经元与小鼠]
Rev Neurol. 2003;37(5):447-53.
7
Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons.Ca2+通道β3亚基的靶向破坏降低了N型和L型Ca2+通道活性，并改变了神经元中P/Q型Ca2+通道的电压依赖性激活。
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12010-5. doi: 10.1073/pnas.95.20.12010.
8
Linking calcium-channel isoforms to potential therapies.将钙通道亚型与潜在疗法联系起来。
Curr Opin Investig Drugs. 2008 Jul;9(7):707-15.
9
Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons.鉴定调节交感神经元中Ca2+和K+通道活性的毒蕈碱受体亚型。
Life Sci. 2001 Apr 27;68(22-23):2481-7. doi: 10.1016/s0024-3205(01)01042-6.
10
Effects of extracellular pH on voltage-gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons.细胞外pH值对离体大鼠CA1神经元电压门控性Na+、K+和Ca2+电流的影响。
J Physiol. 1996 Jun 15;493 ( Pt 3)(Pt 3):719-32. doi: 10.1113/jphysiol.1996.sp021417.

引用本文的文献

1
Effects of Risperidone and Aripiprazole Antipsychotic Drugs on Behavioral Changes and the Expression Levels of DRD2, HTR2A, AKT1, and CACNA1C Genes in the Hippocampus of a Ketamine-induced Schizophrenia-like Rat Model.利培酮和阿立哌唑抗精神病药物对氯胺酮诱导的精神分裂症样大鼠模型海马中行为变化及DRD2、HTR2A、AKT1和CACNA1C基因表达水平的影响
J Mol Neurosci. 2025 Aug 12;75(3):106. doi: 10.1007/s12031-025-02403-x.
2
Clustering of Ca 1.3 L-type calcium channels by Shank3.Shank3 介导的 Ca 1.3 型 L 型钙通道聚集。
J Neurochem. 2023 Oct;167(1):16-37. doi: 10.1111/jnc.15880. Epub 2023 Jun 30.
3
Use of Cheminformatics to Determine Potential Drug Interactions between Popular Barbadian Botanical Medicines and Antihypertensive Drugs.
利用化学信息学确定巴巴多斯流行植物药与抗高血压药物之间的潜在药物相互作用。
ACS Omega. 2022 Nov 30;7(49):44603-44619. doi: 10.1021/acsomega.2c02446. eCollection 2022 Dec 13.
4
Role of Ca in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia.钙在健康和病理性心脏功能中的作用：从正常的兴奋-收缩偶联到导致遗传性心律失常的突变。
Arch Toxicol. 2023 Jan;97(1):73-92. doi: 10.1007/s00204-022-03385-0. Epub 2022 Oct 10.
5
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects.抗高血压药物与大脑功能：治疗有益和有害神经精神作用的潜在机制。
Cardiovasc Res. 2023 May 2;119(3):647-667. doi: 10.1093/cvr/cvac110.
6
Genome-wide characterization of RNA editing highlights roles of high editing events of glutamatergic synapse during mouse retinal development.全基因组RNA编辑特征揭示了小鼠视网膜发育过程中谷氨酸能突触高编辑事件的作用。
Comput Struct Biotechnol J. 2022 May 18;20:2648-2656. doi: 10.1016/j.csbj.2022.05.029. eCollection 2022.
7
Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Ca1.2 calcium channel.缺乏 Ca1.2 钙通道替代外显子 33 的小鼠增强的长时程增强和受损的学习能力。
Transl Psychiatry. 2022 Jan 10;12(1):1. doi: 10.1038/s41398-021-01683-2.
8
Mechanisms and physiological implications of cooperative gating of clustered ion channels.簇集离子通道协同门控的机制及生理学意义。
Physiol Rev. 2022 Jul 1;102(3):1159-1210. doi: 10.1152/physrev.00022.2021. Epub 2021 Dec 20.
9
Adenosine-to-inosine RNA editing in neurological development and disease.神经发育和疾病中的腺苷到肌苷 RNA 编辑。
RNA Biol. 2021 Jul;18(7):999-1013. doi: 10.1080/15476286.2020.1867797. Epub 2021 Jan 6.
10
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.钙通道辅助 α2δ1 和 α2δ3 亚基驱动兴奋性和抑制性神经元网络发育。
J Neurosci. 2020 Jun 17;40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020. Epub 2020 May 15.