Yamagami J, Araie M, Shirato S, Ishii R
Department of Ophthalmology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Nippon Ganka Gakkai Zasshi. 1991 May;95(5):495-9.
Around-the clock intraocular pressure (IOP) measurement were performed in 104 eyes of 52 low tension glaucoma (LTG) cases. Subjects were all hospitalized and IOP measurements were done every 2 hours from 6:00 AM to 12:00 PM and every 3 hours from 12:00 PM to 6:00 AM. All LTG patients met the following criteria, (1) glaucomatous optic nerve head change and corresponding visual field defect, (2) normal open angle, (3) IOP less than or equal to 21mmHg at any time of IOP measurement, (4) no obvious neurological or rhinological disorders that could affect the optic nerve, (5) no history of hemodynamic crisis or cardiovascular disorders except mild hypertension. Peak IOPs were most frequently observed at 10:00 AM, but about 55% of all observed peaks were in the time period from 6:00 PM to 8:00 AM. Most troughs were observed from 2:00 PM to 10:00 PM. The mean IOP, the diurnal variation and the difference between both eyes in the same person averaged 14.1, 4.9, and 0.6mmHg, respectively. Assuming that the period of rhythm is 24 hours, the results of IOP measurements fitted a cosine curve using the least square method. In 44% of all eyes, significant correlation coefficient (r greater than or equal to 0.6, p less than 0.05) between the measured and the predicted IOPs was noted, and an equation, IOP = 14.3 + 1.7cos 2 pi (t/24-0.4 radian), was obtained. Comparing the present results with former ones, we concluded that the IOP changes in LTG patients were similar to those in normal individuals.
对52例低眼压性青光眼（LTG）患者的104只眼进行了24小时眼压（IOP）测量。所有受试者均住院，从上午6:00至中午12:00每2小时测量一次眼压，从中午12:00至上午6:00每3小时测量一次。所有LTG患者均符合以下标准：（1）青光眼性视神经乳头改变及相应的视野缺损；（2）正常开角；（3）眼压测量的任何时间眼压均小于或等于21mmHg；（4）无明显的可能影响视神经的神经或鼻科疾病；（5）除轻度高血压外无血流动力学危机或心血管疾病史。眼压峰值最常出现在上午10:00，但所有观察到的峰值中约55%出现在下午6:00至上午8:00之间。大多数谷值出现在下午2:00至晚上10:00之间。同一人双眼的平均眼压、昼夜变化及差值分别为14.1、4.9和0.6mmHg。假设节律周期为24小时，眼压测量结果用最小二乘法拟合余弦曲线。在所有眼中，44%观察到测量眼压与预测眼压之间有显著相关系数（r大于或等于0.6，p小于0.05），并得到一个方程：眼压=14.3+1.7cos 2π（t/24 - 0.4弧度）。将目前的结果与以前的结果进行比较，我们得出结论，LTG患者的眼压变化与正常个体相似。
