后海马体的体积与重度抑郁症患者的缓解率相关。
Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.
作者信息
MacQueen Glenda M, Yucel Kaan, Taylor Valerie H, Macdonald Kathryn, Joffe Russell
机构信息
Mood Disorders Program, St. Joseph's Healthcare Hamilton, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
出版信息
Biol Psychiatry. 2008 Nov 15;64(10):880-3. doi: 10.1016/j.biopsych.2008.06.027. Epub 2008 Aug 22.
BACKGROUND
The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment.
METHODS
We compared regional (head and body/tail) HC volumes in 46 patients with MDD, 14 of whom remitted after 8 weeks of first treatment to HC volumes of 32 patients who were not in remission after 8 weeks.
RESULTS
Patients who remitted had larger pretreatment hippocampal body/tail volumes bilaterally compared with those who were not in remission at 8 weeks. This difference was not apparent in either the right or left hippocampal head.
CONCLUSIONS
These findings extend a small number of previous reports, suggesting that regional brain volumes might be associated with rate and extent of clinical response to antidepressant medication.
背景
复发性重度抑郁症（MDD）患者的海马体（HC）较小，但很少有纵向研究探讨其体积是否与治疗反应等具有临床意义的结果相关。
方法
我们比较了46例MDD患者的区域（头部和体部/尾部）HC体积，其中14例在首次治疗8周后缓解，将其与32例8周后未缓解患者的HC体积进行比较。
结果
与8周时未缓解的患者相比，缓解的患者双侧海马体体部/尾部的预处理体积更大。这种差异在右侧或左侧海马体头部均不明显。
结论
这些发现扩展了先前少数报告的内容，表明区域脑体积可能与抗抑郁药物临床反应的速度和程度相关。
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