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用于预测髋部骨折手术患者30天死亡率的术前评分系统的开发与验证

Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery.

作者信息

Maxwell M J, Moran C G, Moppett I K

机构信息

Department of Anaesthesia, University of Nottingham, Queen's Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.

出版信息

Br J Anaesth. 2008 Oct;101(4):511-7. doi: 10.1093/bja/aen236. Epub 2008 Aug 21.

Abstract

BACKGROUND

Hip fractures are common in the elderly and have a high 30 day postoperative mortality. The ability to recognize patients at high risk of poor outcomes before operation would be an important clinical advance. This study has determined key prognostic factors predicting 30 day mortality in a hip fracture population, and incorporated them into a scoring system to be used on admission.

METHODS

A cohort study was conducted at the Queen's Medical Centre, Nottingham, over a period of 7 yr. Complete data were collected from 4967 patients and analysed. Forward univariate logistic regression was used to select the independent predictor variables of 30 day mortality, and then multivariate logistic regression was applied to the data to construct and validate the scoring system.

RESULTS

The variables found to be independent predictors of mortality at 30 days were: age (66-85 yr, > or =86 yr), sex (male), number of co-morbidities (> or =2), mini-mental test score (< or =6 out of 10), admission haemoglobin concentration (< or =10 g dl(-1)), living in an institution, and presence of malignant disease. These variables were subsequently incorporated into a risk score, the Nottingham Hip Fracture Score. The number of deaths observed at 30 days, and the number of deaths predicted by the scoring system, indicated good concordance (chi(2) test, P=0.79). The area (SE) under the receiver operating characteristic curve was 0.719 (0.018), which demonstrated a reasonable predictive value for the score.

CONCLUSIONS

We have developed and validated a scoring system that reliably predicts the probability of mortality at 30 days for patients after hip fracture.

摘要

背景

髋部骨折在老年人中很常见,术后30天死亡率很高。术前识别预后不良高风险患者的能力将是一项重要的临床进展。本研究确定了预测髋部骨折患者30天死亡率的关键预后因素,并将其纳入入院时使用的评分系统。

方法

在诺丁汉女王医疗中心进行了一项为期7年的队列研究。收集了4967例患者的完整数据并进行分析。采用向前单因素逻辑回归选择30天死亡率的独立预测变量,然后对数据应用多因素逻辑回归以构建和验证评分系统。

结果

发现30天死亡率的独立预测变量为:年龄(66 - 85岁、≥86岁)、性别(男性)、合并症数量(≥2)、简易精神状态检查评分(10分中≤6分)、入院时血红蛋白浓度(≤10 g dl⁻¹)、居住在机构中以及存在恶性疾病。这些变量随后被纳入一个风险评分,即诺丁汉髋部骨折评分。观察到的30天死亡人数与评分系统预测的死亡人数显示出良好的一致性(卡方检验,P = 0.79)。受试者工作特征曲线下的面积(标准误)为0.719(0.018),这表明该评分具有合理的预测价值。

结论

我们已经开发并验证了一种评分系统,该系统能够可靠地预测髋部骨折患者术后30天的死亡概率。

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