Mamalui-Hunter Maria, Li Harold, Low Daniel A
Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, St Louis, MO 63110, USA.
Phys Med Biol. 2008 Sep 21;53(18):5139-49. doi: 10.1088/0031-9155/53/18/019. Epub 2008 Aug 22.
Precise mechanical operation of a linear accelerator (linac) is critical for accurate radiation therapy dose delivery. Quantitative procedures for linac mechanical quality assurance (QA) used in the standard of care are time consuming and therefore conducted on a relatively infrequent basis. We present a method for evaluating the mechanical performance of a linac based on a series of projection portal images of a prototype cylindrical phantom with embedded radiopaque fiducial markers. The marker autodetection process included modeling imager response to the radiation beam where the projected cylinder attenuation yielded a non-uniform image background. The linac mechanical characteristics were estimated based on nonlinear multi-objective optimization of the projected marker locations. The estimated geometry parameters for the tested commercial model were gantry angle deviation 0.075 +/- 0.076 degrees (1 SD), gantry sag 0.026 +/- 0.02 degrees , source-to-axis distance SAD 998.3 +/- 1.7 mm, source-to-detector distance SDD 1493 +/- 5.0 mm, couch vertical motion 0.6 +/- 0.45 mm, couch rotation 0.154 +/- 0.1 degrees and average linac rotation center (1.02, -0.27, -0.37) +/- (0.36,0.333,1.20) mm relative to the laser intersection. The imager shift was [-0.44, 2.6] +/- [0.20, 1.1] mm and the imager orientation was in-plane rotation 0.05 +/- 0.03 degrees , roll -0.14 +/- 0.09 degrees and pitch -0.9 +/- 0.604 degrees . The performance of this procedure concerning marker detection and optimization was examined by comparing the detected set of marker coordinates to its back-calculated counterpart for three subgroups of markers: central, wall and intermediate relative to the center of the phantom. The maximum difference was less than 0.25 mm with a mean of 0.146 mm and a standard deviation of 0.07 mm. The clinical use of this automated procedure will allow more efficient, more thorough, and more frequent mechanical linac QA.
直线加速器(linac)的精确机械操作对于准确的放射治疗剂量输送至关重要。护理标准中使用的直线加速器机械质量保证(QA)定量程序耗时较长,因此相对不经常进行。我们提出了一种基于带有嵌入式不透射线基准标记的原型圆柱形体模的一系列投影门静脉图像来评估直线加速器机械性能的方法。标记自动检测过程包括对成像器对辐射束的响应进行建模,其中投影圆柱体的衰减产生不均匀的图像背景。基于投影标记位置的非线性多目标优化来估计直线加速器的机械特性。测试的商业模型的估计几何参数为:机架角度偏差0.075±0.076度(1标准差),机架下垂0.026±0.02度,源轴距SAD 998.3±1.7毫米,源到探测器距离SDD 1493±5.0毫米,治疗床垂直运动0.6±0.45毫米,治疗床旋转0.154±0.1度,相对于激光交叉点的直线加速器平均旋转中心为(1.02,-0.27,-0.37)±(0.36,0.333,1.20)毫米。成像器偏移为[-0.44,2.6]±[0.20,1.1]毫米,成像器方向为平面内旋转0.05±0.03度,滚动-0.14±0.09度,俯仰-0.9±0.604度。通过将检测到的标记坐标集与其针对相对于体模中心的三个标记子组(中央、壁和中间)的反算对应坐标进行比较,检验了该程序在标记检测和优化方面的性能。最大差异小于0.25毫米,平均值为0.146毫米,标准差为0.07毫米。这种自动化程序的临床应用将使直线加速器机械QA更高效、更彻底、更频繁。