Kumar Vikash, Khurana N, Rathi A K, Malhotra Anju, Sharma Kanika, Abhishek Ashu, Bahadur A K
Department of Radiotherapy, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi - 110 002, India.
Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):386-8. doi: 10.4103/0377-4929.42518.
Primitive neuroectodermal tumors (PNETs) are malignant proliferations of small, undifferentiated neuroectodermal cells occurring mainly in children and share the same reciprocal translocation between chromosomes 11 and 22 and the same patterns of biochemical and oncogene expression as osseus and extraosseus Ewing's sarcoma. Some PNETs occur in the brain, while others (the peripheral PNETs) occur in sites outside the brain, such as in the extremities, pelvis and the chest wall. They mostly originate in the chest, pelvis and retroperitoneum; in rare cases, occurrence in the head and neck area has also been seen. We present a rare case of primitive neuroectodermal tumor arising in the prostate gland in a 25-year-old male. To the best of our knowledge, this is the first documentation of a primary peripheral primitive neuroectodermal tumor in the prostate gland of any patient from India and rarely reported in English literature.
原始神经外胚层肿瘤（PNETs）是主要发生于儿童的小型未分化神经外胚层细胞的恶性增殖，与骨和骨外尤因肉瘤具有相同的11号和22号染色体之间的相互易位以及相同的生化和癌基因表达模式。一些PNETs发生在大脑中，而其他的（外周PNETs）发生在脑外部位，如四肢、骨盆和胸壁。它们大多起源于胸部、骨盆和腹膜后；在罕见情况下，也可见于头颈部区域。我们报告一例25岁男性前列腺原发性神经外胚层肿瘤的罕见病例。据我们所知，这是印度任何患者前列腺原发性外周原始神经外胚层肿瘤的首次记录，且在英文文献中鲜有报道。
