Department of Pathology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan.
Diagn Pathol. 2012 Dec 7;7:173. doi: 10.1186/1746-1596-7-173.
Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1-0.2% of all prostatic cancers. Detailed characteristics of the tumor are still unclear due to its rarity.We describe a case of prostatic stromal sarcoma in a 63 year-old man who suffered from urinary obstructive symptoms. Palliative transuterine resection was performed and the preliminary histopathological diagnosis was neuroendocrine carcinoma. After chemotherapy, total pelvic exenteration was performed. Histopathologically, the tumor was composed of monotonously proliferating small to medium-sized round cells, which existed in compact islands with loose or dense fibrovascular networks. Immunohistochemically, the tumor cells were widely positive for vimentin, CD56, CD99 and focally positive for synaptophysin, CD10, progesterone receptor, desmin and CD34, but negative for EMA, cytokeratin, estrogen receptor, S-100 and myoglobin. Most of the previously reported tumors exhibited positive stainability for CD10 and progesterone receptor. In addition to these markers, expressions of CD56, CD99 and synaptophysin were characteristically detected in our case. To the best of our knowledge, we present the first case of prostatic stromal sarcoma with characteristic immunohistochemical staining properties. Although the biological characteristics of this rare tumor have not yet been elucidated, these findings suggest prostatic stromal sarcoma can potentially show neuroectodermal differentiation.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7291874028051262.
前列腺基质肉瘤是一种相当罕见的肿瘤，约占所有前列腺癌的 0.1-0.2%。由于其罕见性，肿瘤的详细特征尚不清楚。我们描述了一例 63 岁男性前列腺基质肉瘤病例，该患者患有排尿梗阻症状。进行了姑息性经子宫切除术，初步组织病理学诊断为神经内分泌癌。化疗后，行全盆腔切除术。组织病理学上，肿瘤由单调增殖的中小圆形细胞组成，存在于疏松或致密的纤维血管网络的致密岛中。免疫组织化学染色，肿瘤细胞广泛表达波形蛋白、CD56、CD99，局灶性表达突触素、CD10、孕激素受体、结蛋白和 CD34，但不表达 EMA、细胞角蛋白、雌激素受体、S-100 和肌红蛋白。以前报道的大多数肿瘤均表现出 CD10 和孕激素受体阳性染色。除了这些标志物外，我们的病例还特征性地检测到 CD56、CD99 和突触素的表达。据我们所知，我们首次报道了具有特征性免疫组织化学染色特性的前列腺基质肉瘤病例。尽管这种罕见肿瘤的生物学特征尚未阐明，但这些发现表明前列腺基质肉瘤可能具有神经外胚层分化的潜能。
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