肺孢子菌抗体反应与慢性阻塞性肺疾病严重程度的关系。
Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease.
作者信息
Morris Alison, Netravali Mahesh, Kling Heather M, Shipley Timothy, Ross Ted, Sciurba Frank C, Norris Karen A
机构信息
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
出版信息
Clin Infect Dis. 2008 Oct 1;47(7):e64-8. doi: 10.1086/591701.
Abstract
Pneumocystis colonization has been associated with severity of chronic obstructive pulmonary disease (COPD). The relationship of Pneumocystis antibody status to COPD severity has not been investigated, but antibody levels might relate to both colonization susceptibility and COPD progression. We investigated anti-Pneumocystis antibody titers and airway obstruction in a cohort of patients with COPD. Undetectable anti-Pneumocystis antibody titer was an independent predictor of more-severe airway obstruction, although use of inhaled corticosteroids is a possible confounder of this effect.
摘要
肺孢子菌定植与慢性阻塞性肺疾病（COPD）的严重程度相关。肺孢子菌抗体状态与COPD严重程度之间的关系尚未得到研究，但抗体水平可能与定植易感性和COPD进展均有关。我们在一组COPD患者中调查了抗肺孢子菌抗体滴度与气道阻塞情况。抗肺孢子菌抗体滴度检测不到是更严重气道阻塞的独立预测因素，尽管吸入性糖皮质激素的使用可能是这种效应的一个混杂因素。
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