Short F, James V H
Department of Chemical Pathology, St Mary's Hospital, London, UK.
Ann Clin Biochem. 1991 May;28 ( Pt 3):218-25. doi: 10.1177/000456329102800303.
To ascertain the use being made of a Supraregional Assay Service laboratory in the diagnosis of primary hyperaldosteronism, follow-up data were obtained on 60 patients in whom the diagnosis was suggested by the biochemical results. In 36 patients an adrenal adenoma had been removed; 14 patients had evidence of an adenoma on CT scan; 10 patients were presumed to have bilateral adrenal hyperplasia. The data used to make the diagnosis of primary hyperaldosteronism and to assess the likelihood of the presence of an adenoma indicate that patients studied at 40 centres in the UK show results very similar to those of North American series where large numbers of patients have been described but all have been studied in the same centre. The majority of patients in our series were treated at the hospital at which the diagnosis was made, thus avoiding referral to a centre distant from the patient's home and indicating that the service was being used as originally intended when the Supraregional Assay Service was set up.
为确定超区域检验服务实验室在原发性醛固酮增多症诊断中的应用情况，我们获取了60例生化检查结果提示该诊断的患者的随访数据。其中36例患者的肾上腺腺瘤已被切除；14例患者的CT扫描显示有腺瘤迹象；10例患者推测为双侧肾上腺增生。用于诊断原发性醛固酮增多症以及评估腺瘤存在可能性的数据表明，在英国40个中心接受研究的患者所显示的结果与北美系列研究非常相似，北美系列研究描述了大量患者，但所有患者均在同一中心接受研究。我们系列中的大多数患者在做出诊断的医院接受治疗，从而避免了转诊至远离患者家庭的中心，这表明超区域检验服务在设立时其用途得到了如预期般的使用。
