Malle E, Sodin-Semrl S, Kovacevic A
Center of Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, A-8010 Graz, Austria.
Cell Mol Life Sci. 2009 Jan;66(1):9-26. doi: 10.1007/s00018-008-8321-x.
The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by inflammation- associated cytokines and a high concentration of circulating SAA may represent an ideal marker for acute and chronic inflammatory diseases. However, SAA is also synthesized in extrahepatic tissues, e.g. human carcinoma metastases and cancer cell lines. An increasing body of in vitro data supports the concept of involvement of SAA in carcinogenesis and neoplastic diseases. Accumulating evidence suggests that SAA might be included in a group of biomarkers to detect a pattern of physiological events that reflect the growth of malignancy and host response. This review is meant to provide a broad overview of the many ways that SAA could contribute to tumour development, and accelerate tumour progression and metastasis, and to gain a better understanding of this acute-phase reactant as a possible link between chronic inflammation and neoplasia.
急性期蛋白血清淀粉样蛋白A（SAA）的合成主要受炎症相关细胞因子调控，循环中高浓度的SAA可能是急慢性炎症性疾病的理想标志物。然而，SAA也在肝外组织中合成，例如人类癌转移灶和癌细胞系。越来越多的体外数据支持SAA参与致癌作用和肿瘤性疾病的概念。越来越多的证据表明，SAA可能被纳入一组生物标志物中，以检测反映恶性肿瘤生长和宿主反应的生理事件模式。本综述旨在广泛概述SAA促进肿瘤发展、加速肿瘤进展和转移的多种方式，并更好地理解这种急性期反应物作为慢性炎症与肿瘤形成之间可能联系的情况。
