Dahnke Hannes, Liu Wei, Herzka Daniel, Frank Joseph A, Schaeffter Tobias
Medical Imaging Systems Sector, Philips Research Europe, Hamburg, Germany.
Magn Reson Med. 2008 Sep;60(3):595-603. doi: 10.1002/mrm.21478.
Local susceptibility gradients result in a dephasing of the precessing magnetic moments and thus in a fast decay of the NMR signals. In particular, cells labeled with superparamagnetic iron oxide particles (SPIOs) induce hypointensities, making the in vivo detection of labeled cells from such a negative image contrast difficult. In this work, a new method is proposed to selectively turn this negative contrast into a positive contrast. The proposed method calculates the susceptibility gradient and visualizes it in a parametric map directly from a regular gradient-echo image dataset. The susceptibility gradient map is determined in a postprocessing step, requiring no dedicated pulse sequences or adaptation of the sequence before and during image acquisition. Phantom experiments demonstrated that local susceptibility differences can be quantified. In vivo experiments showed the feasibility of the method for tracking of SPIO-labeled cells. The method bears the potential also for usage in other applications, including the detection of contrast agents and interventional devices as well as metal implants.
局部磁化率梯度会导致进动磁矩失相,从而使核磁共振信号快速衰减。特别是,用超顺磁性氧化铁颗粒(SPIO)标记的细胞会产生低信号强度,使得从这种负性图像对比度中在体内检测标记细胞变得困难。在这项工作中,提出了一种新方法,可将这种负性对比度选择性地转变为正性对比度。所提出的方法直接从常规梯度回波图像数据集中计算磁化率梯度并将其在参数图中可视化。磁化率梯度图是在一个后处理步骤中确定的,在图像采集之前和期间不需要专门的脉冲序列或对序列进行调整。模型实验表明局部磁化率差异可以被量化。体内实验证明了该方法用于追踪SPIO标记细胞的可行性。该方法还具有用于其他应用(包括造影剂和介入装置以及金属植入物的检测)的潜力。
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