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[皮肤疱疹病毒感染与恶性血液疾病。流行病学]

[Cutaneous herpesvirus infections and malignant blood disorders. Epidemiology].

作者信息

Durand M, Reiffers J, Hoerni-Simon G, Chauvergne J, Hoerni B

出版信息

Bull Cancer. 1976 Jul-Sep;63(3):433-40.

PMID:187272
Abstract

One hundred and ten skin infections with herpes virus were seen in a uniform group of 1,002 lymphoma-leukaemias dominated by non-Hodgkin's lymphoma (385) and Hodgkin's Disease (327). They appeared with a significantly increased frequency in the course of Hodgkin's Disease, and between the ages of 60 and 69 for the other groups. In the Hodgkin's cases they appeared characteristically during complete remission and in the others during the active phase of their disease. Only exceptionally was there evidence of contact infection. Also these infections seemed mainly due to the re-awakening of a latent virus infection as against a failure of natural defense mechanisms of the organism, which the disease itself and the therapeutic regime might alter in a variable fashion.

摘要

在一组1002例以非霍奇金淋巴瘤(385例)和霍奇金病(327例)为主的淋巴瘤白血病患者中,观察到110例皮肤疱疹病毒感染。在霍奇金病病程中,其出现频率显著增加,在其他组中则在60至69岁之间出现频率较高。在霍奇金病病例中,感染特征性地出现在完全缓解期,而在其他病例中则出现在疾病的活动期。仅有个别病例有接触感染的证据。此外,这些感染似乎主要是由于潜伏病毒感染的重新激活,而非机体自然防御机制的失效,疾病本身和治疗方案可能以不同方式改变自然防御机制。

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