Devin Jessica K, Young Pampee P
University of Texas MD Anderson Cancer Center, Department of Endocrine Neoplasia and Hormonal Disorders, Houston, TX 77030, USA.
Curr Opin Investig Drugs. 2008 Sep;9(9):983-92.
Aging is a major risk factor for the development of cardiovascular disease. Aging is also associated with a decline in the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) axis. This axis impacts endothelial and vascular smooth muscle cell biology, as well as cardiac function. The number of endothelial progenitor cells (EPCs) also decreases with age and is emerging as a surrogate measurement of vascular senescence. Studies suggest that EPCs impact vascular health by modulating vascular repair and function. Current evidence demonstrates that EPC number and function is restored with a GH-mediated increase in serum IGF-1. Modulation of the GH and IGF-1 system may therefore provide a useful therapy in the prevention of age-associated changes in the cardiovascular system and in future regenerative cell-based therapies.
衰老为心血管疾病发生的主要风险因素。衰老还与生长激素（GH）及胰岛素样生长因子-1（IGF-1）轴功能减退相关。该轴影响内皮细胞及血管平滑肌细胞生物学特性以及心脏功能。内皮祖细胞（EPCs）数量也随年龄增长而减少，且逐渐成为血管衰老的替代指标。研究表明，EPCs通过调节血管修复及功能来影响血管健康。现有证据表明，血清IGF-1通过GH介导的升高而使EPC数量及功能得以恢复。因此，调节GH及IGF-1系统可能为预防心血管系统的年龄相关变化及未来基于细胞的再生治疗提供有效疗法。
