衰老轴心：端粒、p53 和线粒体。
Axis of ageing: telomeres, p53 and mitochondria.
机构信息
Huffington Center On Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Nat Rev Mol Cell Biol. 2012 May 16;13(6):397-404. doi: 10.1038/nrm3352.
Abstract
Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.
摘要
渐进性 DNA 损伤和线粒体衰退都被认为是自然衰老的主要诱因。传统上，这两条途径在很大程度上是相互独立的。然而，最近的研究揭示了一条分子通路，它通过 p53 将 DNA 损伤直接与受损的线粒体生物发生和功能联系起来。这个衰老轴可能解释了与年龄相关的器官衰退和疾病发展，并为相关治疗药物的开发指明了道路。
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