St John L C, Bell F P
Upjohn Company, Kalamazoo, MI 49001.
Atherosclerosis. 1991 Feb;86(2-3):139-44. doi: 10.1016/0021-9150(91)90209-l.
In the present studies, arterial lipid metabolism was evaluated in the spontaneously hyperlipidemic obese Zucker rat (fa/fa), the lean Zucker rat (Fa/-), and the Sprague-Dawley (SD) rat. Mean serum cholesterol levels in the obese Zucker, lean Zucker and SD rats were 216 +/- 18 mg/dl, 145 +/- 14 mg/dl and 84 +/- 5 mg/dl, respectively. Arterial cholesterol content was in the same rank order as plasma cholesterol and ranged from a mean of 2.23 +/- 0.10 mg/gm wet wt. in the obese rats to 1.36 +/- 0.04 mg/gm wet wt. in the SD rats. The increased arterial sterol in the obese rats was associated with increased lipid metabolism activity. The in vitro incorporation of [14C]oleate into arterial cholesteryl esters was increased 3-4-fold (P less than 0.01) and incorporation into phospholipids and triglycerides was also elevated (P less than 0.001 and P less than 0.01, respectively). The arterial sterol content and arterial lipid metabolism pattern observed in obese Zucker rat aortas are similar to those found in vessels of other species undergoing atherogenic change.
在本研究中，对自发性高脂血症肥胖Zucker大鼠（fa/fa）、瘦Zucker大鼠（Fa/-）和Sprague-Dawley（SD）大鼠的动脉脂质代谢进行了评估。肥胖Zucker大鼠、瘦Zucker大鼠和SD大鼠的平均血清胆固醇水平分别为216±18mg/dl、145±14mg/dl和84±5mg/dl。动脉胆固醇含量与血浆胆固醇呈相同的排序，范围从肥胖大鼠的平均2.23±0.10mg/g湿重到SD大鼠的1.36±0.04mg/g湿重。肥胖大鼠动脉中固醇的增加与脂质代谢活性的增加有关。[14C]油酸体外掺入动脉胆固醇酯的量增加了3 - 4倍（P<0.01），掺入磷脂和甘油三酯的量也升高（分别为P<0.001和P<0.01）。在肥胖Zucker大鼠主动脉中观察到的动脉固醇含量和动脉脂质代谢模式与在发生动脉粥样硬化变化的其他物种的血管中发现的相似。
