Ho S P, Stebler B, Ershler W B
Department of Medicine, University of Wisconsin-Madison.
Lymphokine Cytokine Res. 1991 Apr;10(1-2):101-4.
Mice received interleukin-2 (IL-2) either before and after, or just after intravenous inoculation of syngeneic fibrosarcoma cells. Fewer pulmonary tumor colonies were observed in those animals treated with IL-2, and the best results were observed when IL-2 was administered prior to tumor inoculation. When mice were lethally irradiated and reconstituted with tumor-contaminated bone marrow, IL-2 treatment was also associated with fewer tumor lung colonies. IL-2 may prove to be a useful adjuvant therapy, particularly in the setting of autologous bone marrow transplantation when the infused marrow is contaminated with tumor cells.
小鼠在同基因纤维肉瘤细胞静脉接种之前和之后，或者仅在接种之后接受白细胞介素-2（IL-2）治疗。接受IL-2治疗的动物肺部肿瘤集落较少，且在肿瘤接种前给予IL-2时观察到最佳效果。当小鼠接受致死剂量照射并用受肿瘤污染的骨髓进行重建时，IL-2治疗也与肺部肿瘤集落减少有关。IL-2可能被证明是一种有用的辅助治疗方法，特别是在自体骨髓移植的情况下，当输注的骨髓被肿瘤细胞污染时。
