Arahuetes R M, Carretero V, Diebold Y, Rua C
Departamento de Biología Animal II (Fisiología Animal), Universidad Complutense, Madrid, España.
Biol Neonate. 1991;59(5):303-13. doi: 10.1159/000243364.
The present study examined the effects of maternal bilateral adrenalectomy and betamethasone treatment on fetal encephalic development, in terms of fetal body weight, brain weight, DNA, protein and lipid content and morphological development. Both influenced the developmental time patterns of fetal brain and cerebellum. Fetuses of adrenalectomized rats had decreased body weights, whereas brain weight was not affected. Maternal adrenalectomy produces in fetal brain a decreased number of cells and increased cell size, while betamethasone treatment of adrenalectomized rats increased cell number, which was not different from control values; cell size remained lower than in control fetuses. Lipid content was increased in the fetuses of betamethasone-treated rats. In terms of morphological development, laminated structures (hippocampus and brain and cerebellar cortex) were the ones most affected.
本研究从胎儿体重、脑重、DNA、蛋白质和脂质含量以及形态发育方面，考察了母体双侧肾上腺切除术和倍他米松治疗对胎儿脑发育的影响。二者均影响胎儿脑和小脑的发育时间模式。肾上腺切除大鼠的胎儿体重降低，而脑重未受影响。母体肾上腺切除术使胎儿脑内细胞数量减少、细胞体积增大，而对肾上腺切除大鼠进行倍他米松治疗则增加了细胞数量，与对照值无差异；细胞体积仍低于对照胎儿。倍他米松治疗大鼠的胎儿脂质含量增加。在形态发育方面，分层结构（海马体、脑和小脑皮质）受影响最大。
