Abel L A, Friedman L, Jesberger J, Malki A, Meltzer H Y
Department of Ophthalmology, Indiana University, Indianapolis 46202-5175.
Biol Psychiatry. 1991 Jun 1;29(11):1063-72. doi: 10.1016/0006-3223(91)90248-k.
The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were examined. Gain in the schizophrenic patients was reduced only at 20 degrees/sec, but for both patient groups, CUS rate at 5 degrees/sec was significantly lower than in normals. Using CUS rate at 20 degrees/sec, the patient groups could be distinguished from each other (the rate for schizophrenic patients being highest, and the rate for affectives the lowest) but neither differed significantly from normals. The diagnostic groups did not differ significantly in mean CUS amplitude, although there was a trend for patients to have larger saccades. Gain-CUS rate correlation was strong in normals but reduced or absent in both patient groups. These results indicate that the ocular motor systems of patients with schizophrenia and affective disorders process eye position error abnormally.
使用低噪声红外眼动图技术，记录了23例精神分裂症患者、16例情感障碍患者和21名正常人对5度/秒和20度/秒等速刺激的平稳跟踪反应。研究了跟踪增益、追赶性扫视（CUS）发生率和幅度及其相互关系。精神分裂症患者的增益仅在20度/秒时降低，但对于两组患者，5度/秒时的CUS发生率均显著低于正常人。以20度/秒时的CUS发生率为指标，可将两组患者区分开来（精神分裂症患者的发生率最高，情感障碍患者的发生率最低），但两组与正常人相比均无显著差异。尽管患者的扫视幅度有增大趋势，但诊断组的平均CUS幅度无显著差异。增益与CUS发生率在正常人中相关性较强，而在两组患者中均降低或不存在。这些结果表明，精神分裂症和情感障碍患者的眼动系统处理眼位误差的方式异常。
