Autret A, Minz M, Beillevaire T, Cathala H P, Castaigne P
C R Acad Hebd Seances Acad Sci D. 1976 Oct 11;283(8):955-7.
The administration of clonidine (300 mug) suppresses REM sleep or strikingly diminishes its duration in Man. The statistical difference with placebo given in a double blind trial is highly significant. This suppression of REM sleep may depend on the stimulation of alpha-adrenergic receptors.
