复发性呼吸道感染患儿的免疫球蛋白G亚类缺陷

Immunoglobulin G subclass deficiency in children with recurrent respiratory tract infections.

作者信息

Jiang L P, Yang X Q, Li C R, Zhang Y W, Wang L J, Shen J

机构信息

Children's Hospital, Chongqing University of Medical Sciences.

出版信息

Chin Med J (Engl). 1991 Feb;104(2):119-23.

PMID:1874010

Abstract

With monoclonal antibodies serum immunoglobulin G(IgG) subclasses were measured in seventy children aged 2 to 13 years with recurrent respiratory tract infections including upper respiratory tract infections, otitis media, sinusitis, asthmatic bronchitis and pneumonia. 211 healthy, aged-matched children served as control. IgG subclass deficiency was found in 19 out of the 70 patients (27.1%, single IgG1 deficiency in 7, IgG2 deficiency in 4, combined IgG1-IgG3 deficiency in 5, IgG1-IgG2-IgG3-IgG4 deficiency, IgG1-IgG2-IgG4 deficiency and IgG2-IgG4 deficiency each in 1). The incidence of IgG subclass deficiencies was in the sequence as follows: IgG1, 20%; IgG2, 10%; IgG3, 8.6% and IgG4, 4.3%. The results suggest that IgG subclass deficiency indicate a common disorder in children with recurrent respiratory tract infections.

摘要

采用单克隆抗体检测了70名2至13岁反复呼吸道感染儿童的血清免疫球蛋白G（IgG）亚类，这些儿童的呼吸道感染包括上呼吸道感染、中耳炎、鼻窦炎、哮喘性支气管炎和肺炎。211名年龄匹配的健康儿童作为对照。70例患者中有19例（27.1%）存在IgG亚类缺陷，其中单纯IgG1缺陷7例，IgG2缺陷4例，IgG1-IgG3联合缺陷5例，IgG1-IgG2-IgG3-IgG4缺陷、IgG1-IgG2-IgG4缺陷和IgG2-IgG4缺陷各1例。IgG亚类缺陷的发生率依次为：IgG1，20%；IgG2，10%；IgG3，8.6%；IgG4，4.3%。结果表明，IgG亚类缺陷是反复呼吸道感染儿童的一种常见病症。