[反复呼吸道感染患儿血清IgG亚类水平与维生素A]

[Serum levels of IgG subclasses and vitamin A in children with recurrent respiratory tract infection].

作者信息

Qian Li, Lu Ji-Rong

机构信息

Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2007 Dec;9(6):557-8.

PMID:18082039

Abstract

OBJECTIVE

The development of recurrent respiratory tract infection (RRTI) is related to vitamin A deficiency and immune function abnormality in children. This study examined serum levels of IgG subclasses and vitamin A in children with recurrent respiratory tract infection.

METHODS

Serum IgG subclasses levels (IgG1, IgG2, IgG3, IgG4) were detected using ELISA and serum vitamin A levels were detected using high performance liquid chromatography-Miller method in 80 children with RRTI (ranged from 2-10 years old). The values were compared with those from 80 aged-matched healthy children.

RESULTS

Serum levels of IgG2 (1.52 +/- 0.18 g/L) and IgG4 (0.22 +/- 0.12 g/L) in children with RRTI were significantly lower than controls (IgG2: 2.23 +/- 0.08 g/L; IgG4: 0.28 +/- 0.01 g/L) (P < 0.05). Serum vitamin A levels in children with RRTI were also significantly lower than controls (1.16 +/- 0.22 micromol/L vs 1.56 +/- 0.12 micromol/L; P < 0.05). IgG2 and IgG4 deficiency (27%) was the most common in 22 RRTI children with vitamin A deficiency.

CONCLUSIONS

Serum levels of IgG subclasses, IgG2 and IgG4, and vitamin A decrease in children with RRTI. There might be some relationship between the decreased IgG2 and IgG4 levels and vitamin A deficiency.

摘要

目的

反复呼吸道感染（RRTI）的发生与儿童维生素A缺乏及免疫功能异常有关。本研究检测了反复呼吸道感染患儿血清IgG亚类及维生素A水平。

方法

采用酶联免疫吸附测定法（ELISA）检测80例年龄在2至10岁的反复呼吸道感染患儿血清IgG亚类水平（IgG1、IgG2、IgG3、IgG4），采用高效液相色谱 - 米勒法检测血清维生素A水平。将这些值与80例年龄匹配的健康儿童的值进行比较。

结果

反复呼吸道感染患儿血清IgG2水平（1.52±0.18g/L）和IgG4水平（0.22±0.12g/L）显著低于对照组（IgG2：2.23±0.08g/L；IgG4：0.28±0.01g/L）（P<0.05）。反复呼吸道感染患儿血清维生素A水平也显著低于对照组（1.16±0.22μmol/L对1.56±0.12μmol/L；P<0.05）。在22例维生素A缺乏的反复呼吸道感染患儿中，IgG2和IgG4缺乏最为常见（27%）。