Coşkun Y, Bayraktaroğlu Z
Department of Pediatrics, Gaziantep University Faculty of Medicine.
Turk J Pediatr. 1997 Jul-Sep;39(3):347-52.
The frequency of major immunoglobulin isotype and IgG subclass deficiencies among 74 children aged six months to 14 years with recurrent infections was studied. All children had at least five to six episodes of respiratory tract infections, while recurrent diarrhea had occurred in eight. Two selective and six partial IgA deficiencies were detected. IgG4, IgG3 and IgG2 deficiencies, either isolated or combined, were found in 13, nine and one patient respectively. Among these there were two combined deficiencies of IgA + IgG4, three of IgA + IgG3, one of IgA + IgG2 + IgG4, one of IgG1 + IgG3 and two of IgG1 + IgG4. There was one patient with panhypogammaglobulinemia. Our results, similar to those of other studies, showed that the occurrence of the Ig isotype, particularly subclass deficiencies, is not uncommon in children with frequent infections.
对74名年龄在6个月至14岁、患有反复感染的儿童的主要免疫球蛋白同种型和IgG亚类缺陷的频率进行了研究。所有儿童至少有五到六次呼吸道感染发作，八名儿童出现反复腹泻。检测到2例选择性IgA缺陷和6例部分性IgA缺陷。分别在13例、9例和1例患者中发现了IgG4、IgG3和IgG2缺陷，这些缺陷可以是单独出现或合并出现。其中有2例IgA + IgG4联合缺陷、3例IgA + IgG3联合缺陷、1例IgA + IgG2 + IgG4联合缺陷、1例IgG1 + IgG3联合缺陷和2例IgG1 + IgG4联合缺陷。有1例全丙种球蛋白低下血症患者。我们的结果与其他研究结果相似，表明在频繁感染的儿童中，Ig同种型尤其是亚类缺陷的发生并不罕见。
