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[胃癌外科治疗中的问题]

[Problems in the surgical treatment of gastric cancers].

作者信息

Chen J Q

机构信息

Cancer Institute, China Medical University, Shenyang.

出版信息

Zhonghua Wai Ke Za Zhi. 1991 Apr;29(4):220-3, 269-70.

PMID:1874107
Abstract

Radical resections were performed in 177 cases of gastric cancer (early cancer 31 cases and advanced cancer 146 cases). R+1 operation was performed in 10 cases and R2 or R3 was in 167. All patients were followed up to the end of the study with the 5-year survival rate of 57.6%. In the patients with normal serosa, cancer was often located in the mucosa. In such situation, R1 or R1+ operation was advisable. In the patients of reactive serosal types, the extent of operation should not be reduced. The serosa were often penetrated by cancer cells in diffusely infiltrated cancer, with a poor prognosis. If measures were not taken to destroy free cancer cells, the 5-year survival rate was very low inspite of radical operations. The number of lymph node metastasis was closely related to the biological behavior of primary cancer. Prognosis was good after R2 or R3 operation when the cancer was still within the gastric wall, Borrmann type 1,2,3, massive or nest growth patterns, and the number of lymph node metastasis was below 5 and within first group (n1). If the number of lymph node metastasis was above 10, metastasis to the second (n2) or third group (n3), the cancer infiltrated to the serosa, Borrmann type 4, diffused growth pattern the prognosis was poor even R2 or R3 operations were performed.

摘要

对177例胃癌患者实施了根治性切除术(早期癌31例,进展期癌146例)。10例行R+1手术,167例行R2或R3手术。所有患者均随访至研究结束,5年生存率为57.6%。在浆膜正常的患者中,癌灶常位于黏膜层。在这种情况下,建议行R1或R1+手术。在反应性浆膜类型的患者中,手术范围不应缩小。在弥漫浸润型癌中,癌细胞常穿透浆膜,预后较差。如果不采取措施消灭游离癌细胞,尽管进行了根治性手术,5年生存率也很低。淋巴结转移数量与原发癌的生物学行为密切相关。当癌仍局限于胃壁内、Borrmann分型为1、2、3型、呈块状或巢状生长模式、淋巴结转移数量低于5个且在第一组(n1)内时,行R2或R3手术后预后良好。如果淋巴结转移数量超过10个、转移至第二组(n2)或第三组(n3)、癌浸润至浆膜、Borrmann分型为4型、呈弥漫性生长模式,即使进行了R2或R3手术,预后也较差。

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