Hoekstra H J, Mehta D M, Wijffels R T, Vermey J, Oldhoff J
Division of Surgical Oncology, Groningen University Hospital, The Netherlands.
Eur J Surg Oncol. 1991 Aug;17(4):364-9.
Patients with locally advanced disease, considered incurable by conventional therapeutic options, were treated, if possible, with surgical resection, and intra-operative radiotherapy (IORT) with or without external beam radiotherapy (EBRT), with the aim of improving local control of disease. Twelve patients were selected for IORT and eight patients were subsequently submitted to IORT in order to achieve local control. There were no IORT related complications, and local tumor control was achieved in all cases with a median follow-up of 22 months. IORT is a new and experimental treatment modality with a potential advantage over conventional radiotherapy.
患有局部晚期疾病、被认为无法通过传统治疗方案治愈的患者，若有可能，接受了手术切除以及术中放疗（IORT），联合或不联合外照射放疗（EBRT），目的是改善疾病的局部控制。选择了12例患者进行术中放疗，随后又有8例患者接受术中放疗以实现局部控制。未出现与术中放疗相关的并发症，所有病例均实现了局部肿瘤控制，中位随访时间为22个月。术中放疗是一种新的实验性治疗方式，相对于传统放疗具有潜在优势。
