El-Tawil Shady G, Adnan Rohana, Muhamed Zaki N, Othman Nor Hayati
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Pathology. 2008 Oct;40(6):600-3. doi: 10.1080/00313020802320622.
To evaluate Fourier transform infrared (FTIR) spectroscopy as new tool for screening of cervical cancer in comparison with cervical cytology.
A total of 800 cervical scrapings were taken by cytobrush and placed in ThinPrep medium. The samples were dried over infrared transparent matrix. Beams of infrared light were directed at the dried samples at frequency of 4000 to 400 cm(-1). The absorption data were produced using a Spectrum BX II FTIR spectrometer. Data were compared with the reference absorption data of known samples using FTIR spectroscopy software. FTIR spectroscopy was compared with cytology (gold standard).
FTIR spectroscopy could differentiate normal from abnormal cervical cells in the samples examined. The sensitivity was 85%, specificity 91%, positive predictive value 19.5% and negative predictive value of 99.5%.
This study suggests that FTIR spectroscopy could be used as an alternative method for screening for cervical cancer.
与宫颈细胞学检查相比，评估傅里叶变换红外光谱（FTIR）作为宫颈癌筛查新工具的效果。
用细胞刷采集800份宫颈刮片，置于ThinPrep培养基中。样本在红外透明基质上干燥。红外光束以4000至400厘米-1的频率照射干燥后的样本。使用Spectrum BX II傅里叶变换红外光谱仪生成吸收数据。使用傅里叶变换红外光谱软件将数据与已知样本的参考吸收数据进行比较。将傅里叶变换红外光谱与细胞学检查（金标准）进行比较。
在检测的样本中，傅里叶变换红外光谱能够区分正常和异常宫颈细胞。灵敏度为85%，特异性为91%，阳性预测值为19.5%，阴性预测值为99.5%。
本研究表明，傅里叶变换红外光谱可作为宫颈癌筛查的替代方法。
