Zamagni C, Martoni A, Ercolino L, Baroni M, Tanneberger S, Pannuti F
Divisione di Oncologia Osp. S. Orsola-Malpighi, Bologna, Italy.
J Chemother. 1991 Apr;3(2):126-9. doi: 10.1080/1120009x.1991.11739078.
Thirty patients with advanced breast cancer, not pretreated with chemotherapy for advanced disease, received a polychemotherapy regimen containing 5-fluorouracil (500 mg/m2 iv), epirubicin (50 mg/m2 iv) and cyclophosphamide (500 mg/m2 iv) every four weeks. All patients were evaluable for response and for toxicity. No complete remissions were observed, while 13 patients (43.5%) achieved a partial remission for a median duration of 46 weeks. The main side-effects were alopecia (grade 2-3 in 57%), leukopenia (grade 3-4 in 33%) and nausea/vomiting (grade 3-4 in 27%). In three cases we observed laboratory signs of cardiotoxicity without clinical symptoms.
30例晚期乳腺癌患者，未接受过晚期疾病的化疗预处理，每四周接受一次包含5-氟尿嘧啶（500mg/m²静脉注射）、表柔比星（50mg/m²静脉注射）和环磷酰胺（500mg/m²静脉注射）的多药化疗方案。所有患者均可评估疗效和毒性。未观察到完全缓解，13例患者（43.5%）达到部分缓解，中位缓解持续时间为46周。主要副作用为脱发（57%为2-3级）、白细胞减少（33%为3-4级）和恶心/呕吐（27%为3-4级）。3例患者观察到心脏毒性的实验室指标但无临床症状。
