Martoni A, Rani P, Ercolino L, Canova N, Pannuti F
Oncology Division, S. Orsola Malpighi Hospital, Bologna, Italy.
Chemioterapia. 1988 Oct;7(5):345-9.
Thirty patients with advanced breast cancer, not pretreated with chemotherapy, received a polychemotherapy regimen containing mitoxantrone, fluorouracil and cyclophosphamide at the dose of 10 mg/m2, 500 mg/m2 and 500 mg/m2 i.v. respectively every 28 days. Out of 25 patients evaluable for response 9 patients achieved a partial remission (36%) for a median duration of 20.5 weeks. The main side effects were leukopenia (grade 3-4 in 70%) and nausea-vomiting (grade 3-4 in 27%). Alopecia was present only in 5 patients (17%). Three patients demonstrated instrumental signs of cardiotoxicity without clinical symptoms.
30例未经化疗预处理的晚期乳腺癌患者接受了一种联合化疗方案，该方案包含米托蒽醌、氟尿嘧啶和环磷酰胺，剂量分别为10mg/m²、500mg/m²和500mg/m²，静脉注射，每28天一次。在可评估疗效的25例患者中，9例患者达到部分缓解（36%），中位缓解持续时间为20.5周。主要副作用为白细胞减少（70%为3-4级）和恶心呕吐（27%为3-4级）。仅5例患者（17%）出现脱发。3例患者表现出心脏毒性的仪器检查征象，但无临床症状。
