Kroenke Kurt, Strine Tara W, Spitzer Robert L, Williams Janet B W, Berry Joyce T, Mokdad Ali H
Department of Medicine, Indiana University School of Medicine and Regenstrief Institute, Indianapolis, IN, United States.
J Affect Disord. 2009 Apr;114(1-3):163-73. doi: 10.1016/j.jad.2008.06.026. Epub 2008 Aug 27.
The eight-item Patient Health Questionnaire depression scale (PHQ-8) is established as a valid diagnostic and severity measure for depressive disorders in large clinical studies. Our objectives were to assess the PHQ-8 as a depression measure in a large, epidemiological population-based study, and to determine the comparability of depression as defined by the PHQ-8 diagnostic algorithm vs. a PHQ-8 cutpoint > or = 10.
Random-digit-dialed telephone survey of 198,678 participants in the 2006 Behavioral Risk Factor Surveillance Survey (BRFSS), a population-based survey in the United States. Current depression as defined by either the DSM-IV based diagnostic algorithm (i.e., major depressive or other depressive disorder) of the PHQ-8 or a PHQ-8 score > or = 10; respondent sociodemographic characteristics; number of days of impairment in the past 30 days in multiple domains of health-related quality of life (HRQoL).
The prevalence of current depression was similar whether defined by the diagnostic algorithm or a PHQ-8 score > or = 10 (9.1% vs. 8.6%). Depressed patients had substantially more days of impairment across multiple domains of HRQoL, and the impairment was nearly identical in depressed groups defined by either method. Of the 17,040 respondents with a PHQ-8 score > or = 10, major depressive disorder was present in 49.7%, other depressive disorder in 23.9%, depressed mood or anhedonia in another 22.8%, and no evidence of depressive disorder or depressive symptoms in only 3.5%.
The PHQ-8 diagnostic algorithm rather than an independent structured psychiatric interview was used as the criterion standard.
The PHQ-8 is a useful depression measure for population-based studies, and either its diagnostic algorithm or a cutpoint > or = 10 can be used for defining current depression.
在大型临床研究中，八项患者健康问卷抑郁量表（PHQ - 8）已被确立为抑郁症有效的诊断和严重程度测量工具。我们的目标是在一项基于人群的大型流行病学研究中评估PHQ - 8作为抑郁测量工具的情况，并确定PHQ - 8诊断算法所定义的抑郁症与PHQ - 8切点≥10所定义的抑郁症之间的可比性。
对2006年美国行为危险因素监测调查（BRFSS）中198,678名参与者进行随机数字拨号电话调查，这是一项基于人群的调查。根据PHQ - 8基于《精神疾病诊断与统计手册》第四版（DSM - IV）的诊断算法（即重度抑郁症或其他抑郁症）或PHQ - 8评分≥10来定义当前抑郁症；受访者的社会人口统计学特征；过去30天内多个健康相关生活质量（HRQoL）领域的损伤天数。
无论通过诊断算法还是PHQ - 8评分≥10来定义，当前抑郁症的患病率相似（9.1%对8.6%）。抑郁症患者在多个HRQoL领域的损伤天数显著更多，并且通过两种方法定义的抑郁症组中的损伤情况几乎相同。在17,040名PHQ - 8评分≥10的受访者中，重度抑郁症患者占49.7%，其他抑郁症患者占23.9%，情绪低落或快感缺失患者占另外22.8%，仅有3.5%没有抑郁症或抑郁症状的证据。
使用PHQ - 8诊断算法而非独立的结构化精神科访谈作为标准参照。
PHQ - 8是基于人群研究中一种有用的抑郁测量工具，其诊断算法或切点≥10均可用于定义当前抑郁症。
