Pittau Francesca, Tinuper Paolo, Bisulli Francesca, Naldi Ilaria, Cortelli Pietro, Bisulli Antonietta, Stipa Carlotta, Cevolani Daniela, Agati Raffaele, Leonardi Marco, Baruzzi Agostino
Department of Neurological Sciences, University of Bologna, Bologna, Italy.
Epilepsy Behav. 2008 Nov;13(4):685-92. doi: 10.1016/j.yebeh.2008.05.004. Epub 2008 Aug 26.
A 36-year-old right-handed man, who had experienced partial seizures since the age of 24 every time he played or listened to music with a strong emotional charge, underwent videopolygraphic recording, including autonomic variables, and brain fMRI study during which he listened to both "neutral" and "emotionally charged" music. Three right temporal seizures recorded during videopolygraphic monitoring were elicited by listening to the triggering song. The fMRI study disclosed activation in right acoustic areas during "neutral music," whereas an "emotionally charged melody" provoked widespread activation over the right fronto-temporo-occipital area before seizure onset. The literature review disclosed 110 published cases of musicogenic epilepsy that seemed to suggest a right-sided predominance of the epileptogenic zone. Our results support the role of the right temporal lobe in musicogenic epilepsy and demonstrate that the cerebral areas activated during the period of strong emotion leading to the seizures encompass the auditory cortex activated by neutral music.
一名36岁的右利手男性，自24岁起每次播放或聆听充满强烈情感的音乐时都会经历部分性癫痫发作。该患者接受了视频多导记录，包括自主神经变量，以及脑部功能磁共振成像（fMRI）研究，在此期间他聆听了“中性”和“充满情感”的音乐。视频多导监测期间记录到的三次右侧颞叶癫痫发作是由聆听触发歌曲诱发的。fMRI研究显示，在聆听“中性音乐”时右侧听觉区域激活，而“充满情感的旋律”在癫痫发作前会引起右侧额颞枕区域广泛激活。文献综述揭示了110例已发表的音乐性癫痫病例，似乎表明致痫区右侧优势。我们的结果支持右侧颞叶在音乐性癫痫中的作用，并表明在导致癫痫发作的强烈情感期间激活的脑区包括由中性音乐激活的听觉皮层。
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