揭示胰岛素的阴暗面：穿越血脑屏障之旅 - Suppr

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超能文献

Bringing light to the dark side of insulin: a journey across the blood-brain barrier.

作者信息

Sherwin Robert S

机构信息

Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Diabetes. 2008 Sep;57(9):2259-68. doi: 10.2337/db08-9023.

DOI:10.2337/db08-9023

PMID:18753671

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2518475/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d556/2518475/878a399461b6/zdb0090854360001.jpg

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本文引用的文献

Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.腹内侧下丘脑γ-氨基丁酸能张力增加有助于抑制先前低血糖后的对抗调节反应。

Diabetes. 2008 May;57(5):1363-70. doi: 10.2337/db07-1559. Epub 2008 Mar 28.

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.下丘脑腹内侧核中AMP激活的蛋白激酶在调节对急性低血糖的反调节激素反应中起关键作用。

Diabetes. 2008 Feb;57(2):444-50. doi: 10.2337/db07-0837. Epub 2007 Oct 31.

Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation.腹内侧下丘脑的1型促肾上腺皮质激素释放因子受体促进低血糖诱导的激素反调节。

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E705-12. doi: 10.1152/ajpendo.00136.2007. Epub 2007 Jun 19.

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.下丘脑腹内侧神经元释放的突触谷氨酸是预防低血糖的神经回路的一部分。

Cell Metab. 2007 May;5(5):383-93. doi: 10.1016/j.cmet.2007.04.001.

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Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity.葡萄糖或瘦素对表达神经肽Y的下丘脑神经元的抑制作用需要AMP活化蛋白激酶活性发生变化。

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