Huppertz Berthold, Sammar Marei, Chefetz Ilana, Neumaier-Wagner Peruka, Bartz Clemens, Meiri Hamutal
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.
Fetal Diagn Ther. 2008;24(3):230-6. doi: 10.1159/000151344. Epub 2008 Aug 28.
To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia.
A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA.
In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79.
This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis.
测定正常妊娠和子痫前期孕妇血清胎盘蛋白13（PP13）水平。
一项前瞻性纵向研究，纳入41例正常孕妇、18例早产或宫颈机能不全患者以及4例晚发型子痫前期患者。从妊娠5 - 8周开始，每2 - 4周采集666份孕妇血样（每位患者采集10 - 12份样本），采用酶联免疫吸附测定法检测血清PP13水平。
足月分娩的正常孕妇中，孕早期、孕中期和孕晚期母体血清PP13水平中位数分别从166 pg/ml增长至202 pg/ml和382 pg/ml。子痫前期孕妇在孕早期PP13水平显著降低（7 - 8周时为中位数的0.14倍；与正常孕妇相比，p = 0.005）。孕晚期35 - 36周时，子痫前期孕妇的PP13水平显著高于正常孕妇，为中位数的1.79倍。
这项初步研究表明，孕早期PP13水平低可识别高危妊娠，而孕晚期PP13水平高则先于子痫前期综合征出现，提示合体滋养层细胞坏死。
