De Rosa Salvatore, Pacileo Mario, Sasso Laura, Di Palma Vito, Maietta Paola, Paglia Antonella, Brevetti Linda, Cirillo Plinio, Chiariello Massimo
Division of Cardiology, University of Naples Federico II, Italy.
Monaldi Arch Chest Dis. 2008 Jun;70(2):59-67. doi: 10.4081/monaldi.2008.423.
The deleterious effects of cigarette smoke (CS) on cardiovascular morbidity and mortality are well established. Both active and passive smoking represent a major health hazard for both men and women. The great concerns related to the deleterious effects of CS on cardiovascular disease have been translated into various kinds of social interventions and targeted health policies since ever. The high health impact of cigarette smoking has driven a huge number of researches at the epidemiological, clinical and biological level. Nevertheless, even though many progresses have been made in understanding the mechanisms underlying the high disease burden associated to cigarette smoke, the exact components and the mechanisms by means of which it exerts its effects remain to be completely clarified as yet. The present paper reviews the main observations on the pathophysiology of smoke-related cardiovascular diseases, providing an up-to-date perspective about one of the main cardiovascular killers of our days.
香烟烟雾（CS）对心血管疾病发病率和死亡率的有害影响已得到充分证实。主动吸烟和被动吸烟对男性和女性而言都是重大的健康危害。自始至终，与香烟烟雾对心血管疾病的有害影响相关的重大担忧已转化为各种社会干预措施和针对性的健康政策。吸烟对健康的巨大影响推动了在流行病学、临床和生物学层面上的大量研究。然而，尽管在理解与香烟烟雾相关的高疾病负担背后的机制方面已经取得了许多进展，但香烟烟雾发挥作用的确切成分和机制仍有待完全阐明。本文综述了关于烟雾相关心血管疾病病理生理学的主要观察结果，提供了关于当今主要心血管杀手之一的最新观点。
