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[儿童和青少年的QT间期延长与精神药物:拟议指南]

[QT interval prolongation and psychotropic drugs in children and adolescents: proposed guideline].

作者信息

van Aerde K J, Kalverdijk L J, Reimer A G, Widdershoven J A M

机构信息

Jeroen Bosch Ziekenhuis, afd. Kindergeneeskunde, Hertogenbosch.

出版信息

Ned Tijdschr Geneeskd. 2008 Aug 9;152(32):1765-70.

Abstract

--Several psychotropic drugs that are prescribed to children and adolescents can prolong the QT interval on ECG. QT prolongation can cause a potentially fatal type ofventricular tachycardia known as 'torsade de pointes'. --In 1999, the American Heart Association published a guideline on cardiovascular monitoring of children and adolescents receiving psychotropic drugs. --A similar guideline does not exist in the Netherlands. A survey of Dutch child and adolescent psychiatrists revealed a need for guidelines on QT monitoring in children and adolescents taking psychotropic drugs associated with QT prolongation. --A multidisciplinary panel of professionals drafted a proposed guideline for QT monitoring in patients treated with QT-prolonging psychotropic drugs. --The proposed guideline is summarised in two flowcharts, one for the first consultation and one for follow-up visits.

摘要
  • 几种开给儿童和青少年的精神药物会延长心电图上的QT间期。QT间期延长可导致一种潜在致命的室性心动过速,称为“尖端扭转型室速”。

  • 1999年,美国心脏协会发布了一份关于接受精神药物治疗的儿童和青少年心血管监测的指南。

  • 荷兰不存在类似的指南。一项对荷兰儿童和青少年精神科医生的调查显示,需要为服用与QT间期延长相关的精神药物的儿童和青少年制定QT监测指南。

  • 一个多学科专业小组起草了一份关于接受延长QT间期精神药物治疗患者的QT监测建议指南。

  • 建议指南总结在两个流程图中,一个用于首次咨询,一个用于随访。

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