通过金（I）催化的1,6-二炔的水合环化反应合成2-环己烯酮衍生物
Synthesis of 2-cyclohexenone derivatives via gold(I)-catalyzed hydrative cyclization of 1,6-diynes.
作者信息
Zhang Chen, Cui Dong-Mei, Yao Li-Ying, Wang Bi-Song, Hu Yong-Zhou, Hayashi Teruyuki
机构信息
ZJU-ENS Joint Laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
出版信息
J Org Chem. 2008 Oct 3;73(19):7811-3. doi: 10.1021/jo800974x. Epub 2008 Aug 28.
PMID:18754642
Abstract
The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.
摘要
发现金（I）配合物（甲基三苯基膦金）是1,6 - 二炔进行水合环化反应以形成相应的3 - 甲基己 - 2 - 烯酮衍生物的高效催化剂，产率良好至优异。文中描述了提出的反应机理。
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