唑尼沙胺对孤立性头部震颤的影响。
Effects of zonisamide on isolated head tremor.
作者信息
Song I-U, Kim J-S, Lee S-B, Ryu S-Y, An J-Y, Kim H-T, Kim Y-I, Lee K-S
机构信息
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Eur J Neurol. 2008 Nov;15(11):1212-5. doi: 10.1111/j.1468-1331.2008.02296.x. Epub 2008 Aug 27.
BACKGROUND AND PURPOSE
The medical treatment available for patients with essential tremor (ET) is often inadequate. Furthermore, the efficacy of the medical treatments currently available for patients with ET of cranial nerve areas is less satisfactory than that of the medical treatments available for patients with ET involving the upper extremities. This pilot study was performed to evaluate whether zonisamide (ZNS) is effective in the treatment of patients with isolated head tremor.
METHODS
All subjects with isolated head tremor were randomly treated with either ZNS or propranolol. After a washout period, the subjects were switched to the alternative drug.
RESULTS
ZNS was found to be more effective in the treatment of patients with isolated head tremor than propranolol. No severe adverse effects were reported with either ZNS or propranolol.
CONCLUSION
ZNS may be more useful than propranolol for the treatment of ET patients with head tremor.
背景与目的
原发性震颤（ET）患者现有的药物治疗往往并不充分。此外，目前用于颅神经区域ET患者的药物治疗效果不如用于上肢ET患者的药物治疗效果令人满意。本初步研究旨在评估唑尼沙胺（ZNS）治疗孤立性头部震颤患者是否有效。
方法
所有孤立性头部震颤患者随机接受ZNS或普萘洛尔治疗。经过洗脱期后，患者换用另一种药物。
结果
发现ZNS治疗孤立性头部震颤患者比普萘洛尔更有效。ZNS和普萘洛尔均未报告严重不良反应。
结论
对于有头部震颤的ET患者，ZNS可能比普萘洛尔更有用。
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