膜下微管细胞骨架：异源三聚体G蛋白对微管组装的调控
Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric Gproteins.
作者信息
Roychowdhury Sukla, Rasenick Mark M
机构信息
Department of Biological Sciences, University of Texas, El Paso, TX, USA.
出版信息
FEBS J. 2008 Oct;275(19):4654-63. doi: 10.1111/j.1742-4658.2008.06614.x. Epub 2008 Aug 27.
Abstract
Heterotrimeric Gproteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. Gproteins also interact with microtubules and participate in microtubule-dependent centrosome/chromosome movement during cell division, as well as neuronal differentiation. In recent years, significant progress has been made in our understanding of the biochemical/functional interactions between Gprotein subunits (alpha and betagamma) and microtubules, and the molecular details emerging from these studies suggest that alpha and betagamma subunits of Gproteins interact with tubulin/microtubules to regulate the assembly/dynamics of microtubules, providing a novel mechanism for hormone- or neurotransmitter-induced rapid remodeling of cytoskeleton, regulation of the mitotic spindle for centrosome/chromosome movements in cell division, and neuronal differentiation in which structural plasticity mediated by microtubules is important for appropriate synaptic connections and signal transmission.
摘要
异源三聚体G蛋白通过将信号从细胞表面受体传递到细胞内效应分子来参与信号转导。G蛋白还与微管相互作用，并在细胞分裂以及神经元分化过程中参与依赖微管的中心体/染色体运动。近年来，我们对G蛋白亚基（α和βγ）与微管之间的生化/功能相互作用的理解取得了重大进展，这些研究中出现的分子细节表明，G蛋白的α和βγ亚基与微管蛋白/微管相互作用以调节微管的组装/动态，为激素或神经递质诱导的细胞骨架快速重塑、细胞分裂中中心体/染色体运动的有丝分裂纺锤体调节以及神经元分化提供了一种新机制，其中由微管介导的结构可塑性对于适当的突触连接和信号传递很重要。
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