Allen John A, Halverson-Tamboli Robyn A, Rasenick Mark M
Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Nat Rev Neurosci. 2007 Feb;8(2):128-40. doi: 10.1038/nrn2059. Epub 2006 Dec 29.
Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades. The localization of these proteins in lipid rafts, which is affected by the cytoskeleton, also influences the potency and efficacy of neurotransmitter receptors and transporters. The effect of lipid rafts on neurotransmitter signalling has also been implicated in neurological and psychiatric diseases.
脂筏是质膜上的特殊结构，其脂质组成发生改变，并且与细胞骨架相连。有人提出，这些结构是膜结构域，神经递质信号传导可能通过受体聚集和受体激活信号级联的成分发生。这些蛋白质在受细胞骨架影响的脂筏中的定位，也会影响神经递质受体和转运体的效力和功效。脂筏对神经递质信号传导的影响也与神经和精神疾病有关。
