Leonova M V, Rumiantsev D O, Belousov Iu B
Kardiologiia. 1991 Mar;31(3):13-6.
Some aspects of the antiaggregatory action of calcium antagonists were studied in 50 patients with stable angina pectoris. Dilzem (diltiazem) and cordaphene (nifedipine) were tested for their effects on the erythrocytic component of hemostasis, taking into account their capability of suppressing hemolysis, which made ADP, an important thrombocytic activator, enter the blood flow. The two agents significantly reduce the concentration of plasma ADP, free hemoglobin, diminish mechanical erythrocytic resistance, and block platelet aggregation to a varying degree. A relationship was established between the levels of blood nifedipine and the magnitude of rheological effects. With this, the patients with coronary heart disease showed a good antianginal effect.
在50例稳定型心绞痛患者中研究了钙拮抗剂的抗聚集作用的某些方面。考虑到地尔硫䓬（硫氮䓬酮）和硝苯地平抑制溶血的能力，测试了它们对止血的红细胞成分的影响，溶血会使重要的血小板激活剂二磷酸腺苷（ADP）进入血流。这两种药物显著降低血浆ADP浓度、游离血红蛋白，降低红细胞机械抵抗力，并不同程度地阻断血小板聚集。硝苯地平血药浓度与流变学效应大小之间建立了相关性。在此情况下，冠心病患者显示出良好的抗心绞痛效果。
