Tkaczewski W, Goch J H, Kruszyński G, Ryniec A
III Kliniki Chorób Wewnetrznych IMW w Lodzi.
Pol Tyg Lek. 1990;45(10-11):219-21.
The effect of nifedipine on the aggregation of blood platelets has been studied in patients with coronary heart disease. The study involved 78 males, aged between 36 and 64 years (mean age 51 years). The level of aggregation was evaluated before and after a single nifedipine dose of 10 mg (in 15 patients) and of 20 mg (in 34 patients) as well as before and after the treatment with nifedipine (of 29 patient) with a daily dose of 30 mg for two weeks. Aggregation of blood platelets induced by adenosine--diphosphate in of concentrations 1 microM/ml and of 5 microM/ml were estimated by the Born method. It was found that nifedipine reduces the aggregation of the blood platelets in patients with coronary heart disease following single and long-term treatment.
已对冠心病患者硝苯地平对血小板聚集的影响进行了研究。该研究涉及78名男性，年龄在36至64岁之间（平均年龄51岁）。在单次服用10毫克硝苯地平（15例患者）和20毫克硝苯地平（34例患者）前后以及在29例患者每日服用30毫克硝苯地平治疗两周前后，对血小板聚集水平进行了评估。采用Born法估算浓度为1微摩尔/毫升和5微摩尔/毫升的二磷酸腺苷诱导的血小板聚集情况。结果发现，硝苯地平在单次及长期治疗后均可降低冠心病患者的血小板聚集。
