Yoshinaga Masao, Sameshima Koji, Tanaka Yuji, Arata Michiko, Wada Akihiro, Takahashi Hideto
Department of Pediatrics, National Hospital Organization, Kagoshima Medical Center, Kagoshima, Japan.
Circ J. 2008 Oct;72(10):1594-7. doi: 10.1253/circj.cj-08-0246. Epub 2008 Aug 29.
Little is known regarding the association between numbers of cardiovascular (CV) risk factors and the level of each risk factor in elementary school children based on a longitudinal study.
A descriptive study of 319 obese children aged 6-11 years who participated in a screening program for comorbidity of obesity between 2003 and 2005, and who participated in consecutive years thereafter, was performed. Abdominal obesity, hypertension, dyslipidemia (low high-density lipoprotein-cholesterol levels and/or high triglyceride levels), and raised fasting glucose levels were used as the CV risk factors. Metabolic syndrome and each CV risk factor were defined using the criteria newly established by a Task Force financed by the Health and Labour Science Research in Japan. An increase in the total number of CV risk factors implied a worsening of each CV risk factor level over a 1-year interval, and vice versa. Abdominal obesity in males and insulin resistance in females were prevalent in children who were at elementary school level.
We should assess not only obesity but all CV risk factor levels, because a cluster of risk factors implies a worsening of the individual risk factor levels in children as young as those in elementary school.
基于一项纵向研究,关于小学儿童心血管(CV)危险因素数量与各危险因素水平之间的关联,目前所知甚少。
对319名6至11岁的肥胖儿童进行了一项描述性研究,这些儿童在2003年至2005年期间参加了肥胖合并症筛查项目,并在之后连续几年参与该项目。腹部肥胖、高血压、血脂异常(低高密度脂蛋白胆固醇水平和/或高甘油三酯水平)以及空腹血糖水平升高被用作心血管危险因素。代谢综合征和各心血管危险因素采用日本厚生劳动科学研究资助的一个特别工作组新制定的标准进行定义。心血管危险因素总数的增加意味着在1年的时间间隔内各心血管危险因素水平恶化,反之亦然。小学阶段的儿童中,男性腹部肥胖和女性胰岛素抵抗较为普遍。
我们不仅应评估肥胖情况,还应评估所有心血管危险因素水平,因为危险因素聚集意味着像小学儿童这样年幼的儿童个体危险因素水平恶化。