Jee Byung Chul, Ku Seung Yup, Suh Chang Suk, Kim Ki Chul, Lee Won Don, Kim Seok Hyun
Department of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seongnam, Korea.
J Korean Med Sci. 2008 Aug;23(4):657-61. doi: 10.3346/jkms.2008.23.4.657.
The aim of this study was to investigate whether serum levels of anti-Müllerian hormone (AMH) and inhibin B at ovulation triggering day correlate with the number of immature oocytes obtained from stimulated in vitro fertilization (IVF) cycles. Fifty-nine consecutive cycles of ovarian hyperstimulation and IVF were selected from 45 women who had tubal (n=18) or unexplained infertility (n=27) and obtained at least one oocyte. Serum levels of AMH and inhibin B at ovulation triggering day were measured by enzyme-linked immunosorbent assay (ELISA). Univariate analysis and multiple regressions revealed that serum AMH or inhibin B levels were significantly correlated with immature oocyte count and the correlation coefficients were higher compared to the mature oocyte count. Serum AMH and inhibin B levels on triggering day seems to be more closely related with the immature oocyte count and thus could be good predictors to determine the immature oocyte count in IVF cycle.
本研究的目的是调查在触发排卵日时血清抗苗勒管激素(AMH)和抑制素B水平是否与体外受精(IVF)促排卵周期中获得的未成熟卵母细胞数量相关。从45例输卵管性不孕(n = 18)或不明原因不孕(n = 27)且至少获得1个卵母细胞的女性中选取59个连续的卵巢过度刺激和IVF周期。采用酶联免疫吸附测定(ELISA)法检测触发排卵日时血清AMH和抑制素B水平。单因素分析和多元回归显示,血清AMH或抑制素B水平与未成熟卵母细胞计数显著相关,且相关系数高于成熟卵母细胞计数。触发日时血清AMH和抑制素B水平似乎与未成熟卵母细胞计数关系更为密切,因此可能是确定IVF周期中未成熟卵母细胞计数的良好预测指标。