Singh Nina, Sun Hsin-Yun
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Liver Transpl. 2008 Sep;14(9):1249-55. doi: 10.1002/lt.21587.
The propensity of liver transplant recipients to develop more fulminant disease presentation and a higher risk of disseminated disease due to a number of opportunistic infections, including invasive aspergillosis, cryptococcosis, zygomycosis, may be related to iron overload. Abnormalities in iron homeostasis may also be a contributor to severe manifestations due to other pathogens such as cytomegalovirus and Staphylococcus aureus in liver transplant recipients. Iron is essential not only for microbial pathogenesis, but directly impairs pivotal pathogen specific host defenses. Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted.
肝移植受者由于多种机会性感染（包括侵袭性曲霉病、隐球菌病、接合菌病）而更易出现暴发性疾病表现以及播散性疾病的风险更高，这可能与铁过载有关。铁稳态异常也可能是肝移植受者因其他病原体（如巨细胞病毒和金黄色葡萄球菌）导致严重表现的一个因素。铁不仅对微生物发病机制至关重要，而且直接损害关键的病原体特异性宿主防御。有必要开展研究以评估肝移植受者的铁稳态以及铁过载导致机会性感染发病机制的相关机制。
