Albtoosh Asma Salameh, Shaf'ei Moayad, Al Hayek Sa'ed, Ramdan Lara Ibrahim, Abu Shahin Nisreen, Alzyoud Mohammad, Farah Randa
Department of Respiratory and Internal Medicine, School of Medicine The University of Jordan Amman Jordan.
Jordan University Hospital Amman Jordan.
Clin Case Rep. 2023 Jun 17;11(6):e7540. doi: 10.1002/ccr3.7540. eCollection 2023 Jun.
Mucormycosis is an opportunistic fungal infection that usually affects patients with diabetes mellitus or immunosuppression. The fungus invades the nearby blood vessels leading to thrombosis and necrosis of the organs involved. Although Mucorales can invade any organ in the body, the gastrointestinal system is an uncommon site for infection. Mucormycosis is a fatal infection, and prompt intervention is required to ensure survival. In this report, we present a case of a 46-year-old man with history of valve replacement surgery on warfarin, who admitted with abdominal pain and life-threatening gastrointestinal bleeding. Esophagogastroduodenoscopy revealed an active gastric ulcer bleeding, and the diagnosis of mucormycosis infection was confirmed with direct microscopy and histopathological evaluation from a tissue . Typically, antifungal therapy alone is inadequate to control mucormycosis infection and surgical intervention is often required. Our patient was successfully treated using antifungal therapy alone. This report presents a rare case of gastrointestinal mucormycosis in setting of valve replacement and was successfully treated with antifungal therapy.
毛霉病是一种机会性真菌感染,通常影响糖尿病或免疫抑制患者。真菌侵入附近血管,导致受累器官血栓形成和坏死。虽然毛霉目可侵入身体任何器官,但胃肠道是少见的感染部位。毛霉病是一种致命感染,需要及时干预以确保存活。在本报告中,我们介绍了一名46岁有瓣膜置换手术史且正在服用华法林的男性患者,他因腹痛和危及生命的胃肠道出血入院。食管胃十二指肠镜检查发现活动性胃溃疡出血,通过直接显微镜检查和组织病理评估确诊为毛霉病感染。通常,单独的抗真菌治疗不足以控制毛霉病感染,常需要手术干预。我们的患者仅用抗真菌治疗即成功治愈。本报告介绍了一例瓣膜置换术后罕见的胃肠道毛霉病病例,并通过抗真菌治疗成功治愈。