紧密连接蛋白-1在胃腺癌侵袭过程中的表达变化
Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion.
作者信息
Wu Yong-Lian, Zhang Sheng, Wang Guo-Rong, Chen Yu-Peng
机构信息
Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.
出版信息
World J Gastroenterol. 2008 Aug 21;14(31):4943-8. doi: 10.3748/wjg.14.4943.
AIM
To investigate the relation of expression transformation of claudin-1 with invasiveness and metastasis of gastric carcinoma.
METHODS
By using immunohistochemistry, expression of claudin-1 in mucosa and invasive front of 136 gastric adenocarcinoma cases and proliferative index (Ki-67) were detected and analyzed.
RESULTS
In mucosa, the claudin-1 over-expression rate of mucinous adenocarcinomas (including signet-ring cell carcinomas) was the highest. It was negatively related with the differentiation but positively related with the invasiveness and metastasis of gastric cancer. In invasive front, the claudin-1 over-expression rate was positively related with the differentiation, invasiveness and metastasis of gastric carcinoma. The expression transformation of claudin-1 was found in gastric carcinoma. The expression of claudin-1 in invasive front was transformed in 28/136 gastric carcinoma cases. The transformation rate in highly differentiated tubular adenocarcinomas was the highest (51.5%, 17/33). The deeper was the invasiveness, the higher was the transformation rate. The claudin-1 expression transformation rate in serosa and omenta was significantly higher (92.9%) than in tunica muscularis of invasive gastric cancer cases, as well as in patients with lymph node metastasis than in those without lymph node metastasis.
CONCLUSION
Up-regulation of claudin-1 expression and its transformation in invasive and metastatic gastric carcinoma suggest that claudin-1 participates in the transformation of biological behaviors in neoplasms. Further study is needed to elucidate the precise mechanism and the relation of claudin-1 expression with the neoplasm progress.
目的
探讨claudin-1表达变化与胃癌侵袭和转移的关系。
方法
采用免疫组织化学方法检测并分析136例胃腺癌患者黏膜及浸润前沿claudin-1的表达情况和增殖指数（Ki-67）。
结果
在黏膜中，黏液腺癌（包括印戒细胞癌）的claudin-1过表达率最高。其与胃癌的分化程度呈负相关，与侵袭和转移呈正相关。在浸润前沿，claudin-1过表达率与胃癌的分化程度、侵袭和转移呈正相关。在胃癌中发现了claudin-1的表达变化。136例胃癌患者中有28例在浸润前沿出现claudin-1表达变化。高分化管状腺癌的变化率最高（51.5%，17/33）。侵袭越深，变化率越高。浸润性胃癌患者浆膜和网膜中的claudin-1表达变化率（92.9%）明显高于肌层，有淋巴结转移患者的变化率高于无淋巴结转移患者。
结论
claudin-1在侵袭性和转移性胃癌中表达上调及其变化提示claudin-1参与肿瘤生物学行为的转变。需要进一步研究以阐明其确切机制以及claudin-1表达与肿瘤进展的关系。
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